Definitely building bigger team since beginning. Being alone on everything for more than two years since 2010 was mind blowing experience. I had to be online 24/7/365 which almost ruined my personal life. That was because I did not recognized for long time how big this is going to be. Now the pool is developed and maintained by team of six professionals (and good friends of me!), which kicked the quality of service to another level.@Marek, thanks for all your contributions to the community!!
Questions:
1) what would you do different in the Pool business knowing what you know now?
Never ending DDoS incidents. Especially on the beginning that was pretty common and I sometimes did not sleep for many days, fighting attacks and moving pool around the world to different datacenters (because after attacks some datacenters refused to host the project).2) What were the biggest challenges in running a pool, starting a pool?
Also physical security was an issue. Pool lost some bitcoins during datacenter hacks, like "Linode hack", where also Bitcoinica lost 40k+ BTC: https://bitcoinmagazine.com/articles/th ... 1330805009. Then we've found a way how to protect our servers in much better way. We run servers in five datacenters around the world and we did not have any security issue since then.
Shortly said, the biggest challenge is to run 24/7 online service with above-bank-grade security with minimal budget. I worked in banking industry before my engagement into bitcoin so I can compare. As far as I can say, our current security model is much higher than any setup banks consider "secure".
Although I never wanted to go into hardware business, it learn me A LOT and I'm thankful for that experience! Both pool business and TREZOR wallet were pretty stressful projects (each in different way). However I regret it only few times3) hind sight 20/20 of course, is there a better niche you could have spent your time? I guess this is simialr to question 1... but if you could do it over again would you still do pools and hardware wallets?

We have third major project in pipeline which (I believe) will have significant impact on Bitcoin. But I prefer to not disclose any details yet!4) The opportunities in Bitcoin are enormous... but what do you think the top 3 are? Is it wallet software? POS deployment? What say you...